General Information

COS-7 Cell Line Origin:

The COS-7 cell line was derived from the kidney of the African Green Monkey, Cercopithecus aethiops. The cells themselves most resemble fibroblast cells in humans and are thus often called COS-7 monkey fibroblast or COS-7 fibroblast-like cells. COS-7 cells are not primary cells. The CV-1 cell line was initiated in the 1960s from an African Green Monkey Kidney. In the early 1980s, the COS-7 line was developed from the CV-1 line by Yakov Gluzman through transformation with a Simian Vacuolating Virus 40 (SV40), a virus that codes for the wild type virus T-antigen.

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Copyright picture from Reproduced with permission from Altogen Biosystems.

COS-7 Cell Line Characteristics:

The result of the transformation of CV-1 to create COS-7 was a cell line that expresses the SV40 T-antigen and retains its susceptibility to SV40, which grows lytically within the kidney cells. The replication of the A209 virus at 40C is also permitted, as are SV40 mutants, so long as mutations (deletions) are in the early regions of the viral genome. Thus, COS is an acronym for CV-1 in Origin, carrying SV40.

In culture, COS-7 cells characteristically display adherent growth to glass and plastic surfaces.


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